منابع مشابه
Ancient lentiviruses leave their mark.
O ne of the most remarkable insights from the human genome project was that more genetic material is devoted to vertically transmitted and defective remnants of once-infectious retroviruses, commonly referred to as endogenous retroviruses (ERVs), than to human protein-coding DNA (1). Current estimates place the ERV component of the human genome at 5–8%, comprising at least 31 distinct families,...
متن کاملCoevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses
Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the co-evolutionary process of PLVs and their hosts associates with viral pathogenicity, and therefore, that elucidating the history of virus-host co-evolution is one of the most intriguing topics in the field of virology. To addres...
متن کاملHost gene evolution traces the evolutionary history of ancient primate lentiviruses.
Simian immunodeficiency viruses (SIVs) have infected primate species long before human immunodeficiency virus has infected humans. Dozens of species-specific lentiviruses are found in African primate species, including two strains that have repeatedly jumped into human populations within the past century. Traditional phylogenetic approaches have grossly underestimated the age of these primate ...
متن کاملCircadian Biology: Rhythms Leave Their Imprint
A recent study has revealed that loss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phenotype, and adipose tissue accumulation.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0701578104